YOUR SYSTEM REPORTED ONLY,赤脚走路有什么好处?
YOUR SYSTEM REPORTED ONLY，赤脚走路有什么好处？
什么是接地？Earthing
顾名思义，接地就是于大地直接接触，大部分人的鞋子是绝缘的，没有和大地直接接触。我们知道，太阳的能量对身体有好处，其实，土地能量也是有能量的，也非常有益于健康。
当我们直接与地面接触，身体会接收一股『能量』，对睡眠、身体和精神状态以及自身免疫功能都有重要影响。自古以来，人类赤脚行走，在田间劳作，与土地亲密接触，自然而然会接收土地能量。
但现在，大多数人都在室内生活，我们住在楼上，睡在床上，塑料、合成纤维、沥青、焦油、乙烯基，阻止了我们与地面的直接接触。
即使我们真的走到户外，鞋子、柏油路面也会阻绝我们与地面连接，天地人本为一体。
强行与地面隔离，缺少和地面的直接接触，很有可能是我们患上某些现代疾病的原因。
其实要改变现状特别简单，只要把鞋子脱掉，到室外走走，回归自然，吸收大地的能量，就能体会到「接地」神奇的治愈能力！
过量的自由基，是万病之源在之前的文章中，我们说过，自由基导致衰老，但是自由基是怎么形成的呢？在人体新陈代谢的过程中，为了获得能量，线粒体需要从呼吸的空气中获得氧气，并从摄入的食物中获得葡萄糖和脂肪。
这两个过程——呼吸和进食，都会产生“活性氧” (ROS)，又叫“自由基”。
很多朋友都知道，低碳饮食可以减少自由基，改善线粒体功能。其实，除了代谢过程，现代人的生活环境中，有很多因素会产生自由基，比如，紫外线、污染、压力、营养不良以及抽烟等。
适量的自由基对身体有益，因为它能消灭掉体内的细菌和病毒，但是，过量就不是一件好事了，因为自由基具有强氧化性，吸收电子能力极强。
它就像极具破坏性的单身汉，非常活跃的从细胞膜上抢夺其他分子上的电子给自己配对，这个过程就是「氧化」。
(氧化的苹果）
但是，当自由基从细胞膜上夺取一个电子后，就产生了另一个新的自由基，并开始了连锁反应。
这个争夺电子的连锁反应会侵蚀细胞膜，导致细胞完整性的丧失，成为各种疾病及身体衰老的源头，所以自由基又被称为衰老之源，百病之源。
简而言之，自由基不能过量，而现代人所处的社会环境，导致我们体内的自由基往往是超标的。
接地可以中和自由基我们知道，自由基的伤害可不小，那怎么减少自由基呢？
第一，是从源头减少自由基的形成
比如减少日晒，释放压力，不吸烟，不熬夜，锻炼，尝试低碳饮食，间歇性断食，遵循真正健康的饮食和生活方式。
第二，是利用抗氧化剂中和自由基
维生素A、C和E，以及富含“多酚”的植物（茶、咖啡、可可等）都是不同类型的抗氧化剂，蔬果和橄榄油中也含有丰富的抗氧化剂。
第三，不穿鞋，接地
大地是最原始、最终极的绿色能源，它具有取之不尽、用之不竭的负离子，这些负离子是最强的抗氧化剂。
众所周知，身体是一个导体，人体一般是带正电，住一楼的人带电少，楼层越高，可能带的正电越多，还有，周边的电气设备越多，处于通电状态，都可能影响你的身体电压。
Electrostatically seen, if 2 conductive objects with different electrical potential, human (+) and earth (-) in this case, are in connection, their charge as good as instantaneously comes into balance. In this natural harmony, our constantly accumulated free radicals are neutralized, the aging process is inhibited, we feel back as fit as a fiddle and our recuperation capability (immune system) works again in optimal condition. The body restores itself very quickly.
而地球带负电，当人体和大地接触的时候，电压会瞬间和大地的电压中和，同时，也会中和长时间积累的自由基。
电压低的情况下，还可能会有助于睡眠，国内原始饮食者易楚，在他的精神飞翔一文中，讲述了他的探索睡眠到精神飞翔的经历。
所以，大地中的负离子，不仅仅可以中和过量的自由基，还可以改善睡眠。
接地还有什么益处我们看很多小孩子都不爱穿袜子，喜欢光脚；而我们去海边，总是特意光着脚在沙滩上走，一会儿就觉得身心舒畅，疲劳尽消。
这些看似随意的行为背后，其实暗含着接地的奇妙功能，实际上，数十项研究表明：
接地可以降低血液黏度、改善心率变异、帮助自主神经系统平衡，减少炎症和皮质醇水平。
→ 接地改善睡眠，缓解失眠
上面我们讲了原理，还有一些相关的研究。
在一项双盲实验中，60名受试者（22名男性和28名女性），他们患有睡眠障碍、慢性肌肉和关节疼痛，且至少六个月。①
研究人员将他们分成两组，让他们都睡在导电碳纤维床垫上，不同的是：
一半的垫子被连连接到卧室窗外的地面上，是真接地
另一半则是“假”接地
一个月后，睡在接地垫子上的实验对象，报告了失眠的改善，而对照组则没有。
Some subjects reported significant relieffrom asthmatic and respiratory conditions, rheumatoid arthritis, PMS, sleepapnea, and hypertension while sleeping grounded.
一些接地对象还报告说，除了失眠，他们的哮喘和呼吸系统疾病、风湿性关节炎、经前综合症、睡眠呼吸暂停和高血压都有明显的缓解。
→ 接地可以缓解压力
科学家发现，在接地过程中，人体内的压力激素皮质醇水平显著降低，皮质醇降低有助于控制血糖水平，调节新陈代谢，并减少炎症，提高记忆力。
在一项实验中，12名参与者接受了接地治疗，下图显示了他们接地8周后，皮质醇水平的变化：压力激素皮质醇的水平明显降低。②
（接地八周后受试者的皮质醇水命明显降低）
除了压力变小外，参与者还表示他们的入睡速度变快了，所有人在夜间醒来的次数减少，早晨和白天也更有活力和能量。
→ 接地可以维护神经系统健康
之前我们说过，迷走神经是自主神经系统中最大的神经，从大脑延伸到结肠，在心脏、肺和消化功能中起着关键作用。
强烈的迷走神经张力，可以帮助缓解压力，更快的放松，而虚弱的迷走神经张力则与慢性炎症有关，现代人80%的疾病来自于炎症，包括心血管疾病、2型糖尿病和某些癌症。
迷走神经张力，通常是通过测量吸气和呼气时心率变化来评估的，在一项研究中，接地可以改善心率，从而改善早产婴儿的迷走神经张力。③
在另一项对成人的研究中，2个小时的接地，可以降低了受试者的炎症和血液黏度，这是心脏病的危险因素。④
→ 接地可以改善炎症，减少身体疼痛
下面图片显示了一位44岁女性热成像图，她经常感到四肢僵硬和疼痛。⑤
在图中，“热”区域就是所谓的炎症区域，第一张是在接地前拍摄的，第二张是在接地30分钟后拍摄的。
在连续『接地睡眠』四个晚上后，她的炎症区域急剧减少，并且：
疼痛减少30%
干扰睡眠的疼痛减少70%
早晨的四肢僵硬和疼痛减少了70%
八周后，它表示，疼痛完全消失了，接地睡眠真的很神奇。
如何才能接地，怎么做？有很多方法可以帮助接地，据报道，在日本，他们建议小孩子的鞋子，不用橡皮鞋底，就是因为橡皮或塑料不会导电，穿着这类鞋子就是与地球绝缘。
（ 接地豆豆皮鞋）
国外有很多人专门买接地鞋，成年人也可以改穿皮鞋，或直接脱掉鞋袜，去户外感受来自大自然的按摩。
下面这些方法可以帮助你更多的接地：
1、经常赤脚在土地、沙滩、泥土上行走，坐卧，在沙滩等湿地上效果最好（湿地导电性更强）。
2、坐在地上、椅子上，让双脚直接接触大地，如果担心安全和卫生问题，也可以在地面上铺一张毯子或毛巾，把脚放在上面。
3、在海洋、湖泊或其他自然水域游泳。
4、坐在树下，靠在树干上。
5、使用室内接地设备（接地床单、接地床垫、接地垫、接地鞋）和家里接地插头连接。
6、如果你还保持着一颗童心，不妨像孩子一样玩土，玩沙，多和大地接触吧。
总之，想办法多与大地接触，晚上睡觉的时候也可以用铜线把床垫和地线连接。
关键的瘦龙说接地，这其实也是原始饮食的理念，国外原始饮食比较流行，所以，国外很多人不穿鞋，流行接地鞋，拒绝绝缘橡胶鞋，就是为了从大地中获得能量。
地球就像一个巨大的电池，里面有一种天然的、微妙的电荷——一种特殊的能量存在于地面。
为了安全与稳定，大部分东西都与它相连，无论是发电厂还是冰箱，抑或是人类，都应该“扎根”于大地，脚踏实地，我们也会感受到愉悦和正能量。
匹兹堡大学生物学博士James Oschman说，赤脚行走，能提高人的幸福感，而出于各种原因，我们减少了和地面的直接接触。
以前有个特流行的词叫“接地气”，我想，人们都渴望接地气，喜欢真实的自己。
如果你也有精力不好的问题，睡眠问题，那就多到干净的草地上，或者是沙滩上，感受一下真正的接地气吧！
该如何回复SCI审稿人？
如何回复SCI投稿审稿人意见（1）
1.所有问题必须逐条回答。
2.尽量满足意见中需要补充的实验。
3.满足不了的也不要回避，说明不能做的合理理由。
4.审稿人推荐的文献一定要引用，并讨论透彻。
以下是本人对审稿人意见的回复一例，仅供参考。
续两点经验：
1，最重要的是逐条回答，即使你答不了，也要老实交代；不要太狡猾，以至于耽误事；
2，绝大部分实验是不要真追加的，除非你受到启发，而想该投另外高档杂志----因为你既然已经写成文章，从逻辑上肯定是一个完整的“story” 了。
以上指国际杂志修稿。国内杂志太多，以至于稿源吃紧，基本没有退稿，所以你怎么修都是接受。
我的文章水平都不高，主要是没有明显的创新性，也很苦恼。但是除了开始几篇投在国内杂志外，其他都在国际杂志（也都是SCI）发表。以我了解的情况，我单位其他同志给国内杂志投稿，退稿的极少，只有一次被《某某科学进展》拒绝。究其原因，除了我上面说的，另外可能是我单位写稿子还是比较严肃，导师把关也比较严的缘故。
自我感觉总结（不一定对）：
1）国内杂志审稿极慢（少数除外），但现在也有加快趋势；
2）国内杂志编辑人员认真负责的人不多，稿子寄去后，少则几个月，多则一年多没有任何消息；
3）国内杂志要求修改的稿子，如果你自己不修，他最后也给你发；
4）国外杂志要求补充实验的，我均以解释而过关，原因见少帖）。还因为：很少杂志编辑把你的修改稿再寄给当初审稿人的，除非审稿人特别请求。编辑不一定懂你的东西，他只是看到你认真修改，回答疑问了，也就接受了（当然高档杂志可能不是这样，我的经验只限定一般杂志（影响因子1-5）。
欢迎大家批评指正。
我常用的回复格式，呵呵。
Dearreviewer:
Iam very grateful to your comments for the manuscript. According with youradvice, we amended the relevant part in manuscript. Some of your questions wereanswered below.
1）
2）
....
引用审稿人推荐的文献的确是很重要的，要想办法和自己的文章有机地结合起来。至于实验大部分都可以不用补做，关键是你要让审稿人明白你的文章的重点是什么，这个实验对你要强调的重点内容不是很必要，或者你现在所用的方法已经可以达到目的就行了。最后要注意，审稿人也会犯错误，不仅仅是笔误也有专业知识上的错误，因为编辑找的审稿人未必是你这个领域的专家。只要自己是正确的就要坚持。在回复中委婉地表达一下你的意见，不过要注意商讨语气哦！
我得回复格式是这样的：
DearProfessor xx:
Thankyou very much for your letter dated xxx xx xxxx, and the referees’ reports.Based on your comment and request, we have made extensive modification on theoriginal manuscript. Here, we attached revised manuscript. in the formats ofboth PDF and MS word, for your approval. A document answering every questionfrom the referees was also summarized and enclosed. A revised manuscript. withthe correction sections red marked was attached as the supplemental materialand for easy check/editing purpose. Should you have any questions, pleasecontact us without hesitate.
然后再附上Q/A，基本上嘱条回答，写的越多越好（老师语）。结果修改一次就接收了：）
我的回复，请老外帮忙修改了
DearEditor:
Thankyou for your kind letter of “......” on November **, 2005. We revised themanuscript. in accordance with the reviewers’ comments, and carefullyproof-read the manuscript. to minimize typographical, grammatical, andbibliographical errors.Here below is our description on revision according tothe reviewers’ comments. Part A (Reviewer 1). The reviewer’s comment: ......
Theauthors’ Answer: .....
2.The reviewer’s comment: ......
Theauthors’ Answer: .....
...
...
PartB(Reviewer 2)
1.The reviewer’s comment: ......
Theauthors’ Answer: .....
2.The reviewer’s comment: ......
Theauthors’ Answer: .....
...
...
Manygrammatical or typographical errors have been revised.All the lines and pagesindicated above are in the revised manuscript.
Thank you and all the reviewers for the kind advice.
Sincerely yours,
***
如何回复SCI投稿审稿人意见(2)
一个回复的例子(已接收)
Major comments:
1.The authors need to strengthen their results by including MMP secretion, andtran-matrigel migration by a positive control progenitor cell population i.e.enriched human CD34 cells obtained from mobilized PBL, since this is a moreclinically relevant source of CD34 cells which has also been shown to secreteboth MMP-9 and MMP-2 (ref. 11). CD34 enriched cells from steady stateperipheral blood which also secrete MMPs are also of interest.
2.In fig1 Cplease specify which cell line represents MMP-negative cells. Thisneeds to be clarified, as well as a better explanation of the method of theprotocol.
3.The ELISA results are represented as "fold increase" compared tocontrol. Instead, we suggest that standards should be used and results shouldbe presented as absolute concentrations and only then can these results becompared to those of the zymography.
4.When discussing the results, the authors should distinguish clearly betweenspontaneous migration vs chemotactic migration.Furthermore, the highspontaneous migration obtained with cord blood CD34 cells should be compared tomobilized PBL CD34 enriched cells and discussed.
5.The authors claim that the clonogenic assay was performed to determine theoptimum concentration for inhibition of MMP activity by phenanthroline and antiMMP-9 mAb, however they should clarify that this assay can only determine thetoxicity of the inhibitors and not their optimal inhibitory concentrations.
Minor comments:
1.There are many spelling and syntax errors, especially in the results anddiscussion, which need correction.
a.Of special importance, is the percent inhibition of migration,which isdescribed as percent of migration. i.e. pg 7:"Migration of CB CD34 wasreduced to 73.3%?" Instead should read "Migration of CB CD34 wasreduced by 73.3%?"
b.The degree symbol needs to be added to the numbers in Materials and methods.
2.It would be preferable to combine figure1Aand B, in order to confirm thereliability of fig. 1B by a positive control (HT1080).
Answer to referee 1 comment:
1.Mobilized peripheral blood is a more clinical source of CD34+ cells, so it isnecessary to compare the MMP-9 secretion and trans-migration ability of CBCD34+ cells with that of mobilized PB CD34+ cells. However, we couldn't obtainenough mobilized PB to separate PB CD34+ cells and determine the MMP-9secretion and migration ability, so we couldn’t complement the study on PBCD34+ cells in this paper. Results obtained by Janowska-Wieczorek et al foundthat mobilized CD34+ cells in peripheral blood express MMP-9.
Furthermore,Domenech’s study showed that MMP-9 secretion is involved in G-CSF induced HPCmobilization. Their conclusions have been added in the discussion. In ourpresent study, our central conclusion from our data is that freshly isolatedCD34+ stem/progenitor cells obtained from CB produce MMP-9.
2.MMP-9 negative cell used in fig1Cwas Jurkat cell. In zymographic analysis,MMP-9 was not detected in the medium conditioned by Jurkat cell. To excludethat the contaminating cells may play a role in the observed MMP-9 production, wescreened the media conditioned by different proportion of CB mononuclear cellswith MMP-9 negative cells by zymography. This result may be confusion.Actually, only by detecting the medium conditioned by 2X105 CB mononuclearcells (MNC)/ml (since the purities of CD34+ cell are more than 90%), it couldexclude the MNC role. In the revised manuscript, we only detected MMP-9activity and antigen level in the medium conditioned by 2X105 CB mononuclearcells (MNC)/ml. There is no MMP-9 secretion be detected in the mediumconditioned by 2X105 CB MNC/ml. It excluded the possibility that the MMP-9activity in CB CD34+ cells conditioned medium is due to the contamination byMNC.
3.In this revised paper, we have detected the MMP-9 antigen levels by usingcommercial specific ELISA kits (R&D System, sensitivity, 0.156ng/ml).Recombinant MMP-9 from R&D System was used as a standard. The results areexpressed in the absolute concentration. The absolute concentration result hasbeen added in the paper. As shown in Fig2, MMP-9 levels were detectable in bothCB CD34+ cell conditioned medium and BM CD34+ cell conditioned medium. However,MMP-9 level was significantly higher in CB CD34+ cell conditioned medium thanin BM CD34+ cell conditioned medium (0.406±0.133ng/ml versus 0.195±0.023ng/ml).Although gelatinolytic activity was not detected in media conditioned by CD34+cells from BM, sensitivity of ELISA favors the detection of MMP-9 antigen inthe BM CD34+.
4.In our study, to establish the direct link between MMP-9 and CB CD34+ cellsmigration, we only determined the role of MMP-9 inspontaneous migration of CBCD34+ cells, but not in chemotactic migration. Actually, regulation ofhematopoietic stem cell migration, homing and anchorage of repopulation cellsto the bone marrow involves a complex interplay between adhesion molecules,chemokines, cytokines and proteolytic enzymes. Results obtained by the groupsof Voermans reveal that not only the spontaneous migration but also the SDF-1induced migration of CB CD34+ cells is greatly increased in comparison to CD34+cells from BM and peripheral blood.
5.CD34+ cells we obtained in each cord blood sample were very limited. It is notenough to screen the inhibitors concentrations to select the optimal inhibitoryconcentrations. In the blocking experiments, based on the concentrations usedby others and the manufacturer's recommendation, we then determined theinhibitors concentrations by excluding the toxicity of the inhibitors in thatconcentration, which was determined by clonogenic assay.
Minor comments:
1.Thespelling and syntax errors have been checked and corrected.
2.Sincethe results in figure1Aand B were obtained from two separated and parallelexperiments, it is not fitness to combine two figures.
这是我的一篇修稿回复，杂志是JBMR-A,影响因子3.652,已发表，供参考！
Replyto the comments on JBMR-A-05-0172
Comment:
Reference#10 is missing from the Introduction but used much later in the manuscript.Should these be in order used in manuscript?
Reply:
Themissing reference has been added into the revised manuscript.
Comment(continued):
What is the sample size for all tests performed?
Reply:
Thesample size for drug release and PCL degradation tests was 3.0×3.0 cm2, with athickness of about0.1mmand a weight of about 40mg. This dada have been addedinto the revised manuscript.
Comment(continued):
Figure7. There is no scientific evidence presented in the TEM figure to convince thisreviewer of sub-jets. This statement on Page 9 cannot be made without clearevidence during the jet formation/separation. Figure 7 is just a large fiberand small fiber fused together, no other conclusion than this can be made.
Reply:
Necessarychange in the statements has been made in the revised manuscript. as well as inthe referred figure accordingly.
Comment(continued):
Table3: Need standard deviation for all values reported not just for a selectfew.Equation after Table 3 not necessary. Just reference method used.
Reply:
Done accordingly.
Comment(continued):
Page11: "faster weight loss" What was the sample size? Where is thestatistical analysis of this data? This reviewer does not see a significantdifference in any of the data presented, thus weight loss would be consideredequivalent.
Reply:
Althoughnot too much difference was seen, the conclusion that “the GS/PCL membraneexhibited a relatively faster weight loss compared with the RT/PCL membrane”was indeed applicable through “one-way analysis of variance (ANOVA)” analysis.Following the reviewer’s comment, a new sub-section has been added to themanuscript. to address the statistical analysis for the data.
Comment(continued):
Page12: What is the sample size for release data? Looks like results based on asample size of one? Need stand deviations on the data presented in Figure 11.Why wasn't release
performedand compared for all electrospun conditions investigated otherwise?
Reply:
Threerepeated tests were performed for each set of measurements and the resultingdata were averaged. As stated in the revised manuscript, each sample had asquare area of 33cm2 with a slightly different thickness.Standarddeviations have been added to the data shown in Fig. 11.The present manuscript.aimed to show that medical drugs can be encapsulated in ultrafine fibersthrough a co-axial electrospinning process. The drug release data intended toshow that the encapsulation was successful. We did not consider any specificapplication in this preliminary paper, and in fact the two drugs were justchosen as model illustration. As such, there seemed not necessary to perform.release experiments for all of the membranes electrospun with differentconditions (i.e. the core concentrations)
Comment(continued):
Table3: Yang's or Young's Modulus (page 10 says Young's).
Reply:
Corrected accordingly.
Comment(continued):
Figure11: What is the % release, not just concentration. Why just this small sampleof release data? Where is the release data for the other conditions?
Reply:
Unfortunately,we did not measure the amount of the shell material in obtaining the compositenanofibers. Namely, the flow rate of the shell solution during theelectrospinning was not accurately controlled using an injecting pump. Hencethe % release was not applicable. Please refer to the previous reply related toPage 12 and Figure 11 for the remaining comments.We acknowledge the reviewer’scomments and suggestions very much, which are valuable in improving the quality of our manuscript.
SCI生物医学英文论文发表成功经验发表成功经验
SCI生物医学英文论文发表成功经验共享系列一---（Clinical Chemistry）
将自己近10年的科研工作中有关论文整理总结发表方面的一些信息贡献出来，与大家共享！如有时间，我拟将一些已经发表的文章，按照撰写与发表的实际经历与过程，即通过案例分析每一个杂志的特色，审稿偏好，review意见及答复要点等逐一分析。可能包含的杂志系列有：naturemethods，clinical chemistry，analyticalchemistry，J. Clin. Immuno，Biomed. Microdev，Front.Biosci，Mol. Cell. Biochem，J.Expert，Rev. Proteomics，Jbiochemistry等。
本章先讲解美国ClinicalChemistry杂志，一个临床化学界的王牌杂志，近年其影响因子逐年攀升，现为7.7分。Clinical Chemistry由美国AACC每月出版，接受的文章包括与人体疾病相关的实验室研究，分析与分子诊断，仪器，资料处理，数据分析，临床研究等投稿。ISSN：0009-9147网络版ISSN：1530-8561
【URL】http://intl.clinchem.org/
【镜像URL】http://www.clinchem.org/
【出版者】AmericanAssociation for Clinical Chemistry (AACC)
【收费情况】免费,全文
【内容简介】
ClinicalChemistry is an international journal of laboratory medicine and moleculardiagnostics.Clinical Chemistry -- This highly respected and often-citedscientific journal is published monthly and contains peer-reviewed methodology,research papers and other articles relevant to clinical chemistry and relatedlaboratory sciences. Its circulation is more than 15,000.David E. Bruns, MD,Editor, (Charlottesville Office)
dbruns@clinchem.aacc.org
SandraWeaver, Senior Editorial Assistant
sweaver@clinchem.aacc.org
DonnaBrandl, Editorial Assistant
dbrandl@clinchem.aacc.org
ShaneP. Cyr, Editorial Assistant
scyr@clinchem.aacc.org
MacFancher, Publisher, (WashingtonOffice)
mfancher@aacc.org
MiriamGonzalez, Publications Coordinator
mgonzalez@aacc.org
【目录、摘要或全文上网等情况】
FreeTOC, 1965 -
Free Abstract, 1975 -
FreeFulltext, 1997 -1999
Fulltext,1997 -
【杂志被索引的情况】
Indexedin Chemical Abstracts.
【备注】
Forfaster access to Clinical Chemistry Online from these countries use this URL:
http://intl.clinchem.orgAustralia, Brazil,China, France, Germany, Hong Kong, Ireland, Israel, Italy, Japan,Mexico,Russia, Singapore, South Africa, South Korea, Spain, Sweden,Switzerland, Taiwan, The Netherlands, UK该杂志是由美国临床化学协会（AmericanAssociation for Clinical Chemistry，AACC）主办的，于1948年成立，总部位于华盛顿，拥有1万余会员。先在网站注册，登记，按照提示一步步提供文章名称，摘要，作者姓名，所属领域，关键词，主文，图表等等。转换为PDF后就可以提交，然后给你一个查询号，接着就是等待了。。。
等了20多天，查阅状态看到了第一次回信：
HomeAuthor Area Reviewer Area Personal Info. ClinChem Home Sign Out Submit NewManuscript. Information for Authors Queue Summary Feedback Help FAQ
DecisionLetter
[Returnto Queue]
To:作者姓名（电子邮件）
From:clinchemed@clinchem.aacc.org
Subject:Clinical Chemistry -- Manuscript. Decision
Cc:
RE:Clinical Chemistry MS ID# CLINCHEM/2002/036332
TITLE:
Dear Dr. xxx:
Yourmanuscript. has been examined by two expert reviewers. Please visit http://submit.clinchem.org to view their comments. For thereasons detailed in these comments, we cannot accept this manuscript. forpublication in Clinical Chemistry in this form. Also, your Reference 28 is notformatted properly. Our Information for Authors will offer assistance withjournal style; it can be found athttp://www.aacc.org/ccj/infoauth.stmWe would consider a revised version thattakes these criticisms into account. If you should resubmit the paper I wouldalso ask that you have several English speaking colleagues proof the paper forgrammar and composition. Additionally, be sure to provide a detailedpoint-by-point response to the comments of the reviewers. Failure to do so willdelay consideration of the revised manuscript.Prior to publication we requirecopyright releases signed by all authors. Our Authors Assurances and Assignmentof Copyright form. can be downloaded from http://www.aacc.org/ccj/auth_assure02.pdf. Please note that all authors must signboth sections of the form. (a signature on the lower section means that allconflicts of interest have been disclosed even if there are none). Send thecompleted form. to us by FAX (434-979-7599).
Sincerely,
Dr.xxx nesley
Associate Editor
P.S.You will find your revised manuscript. can be uploaded in your "Submit aRevision" queue at http://submit.clinchem.org. Please do not begin the submission ofyour revised manuscript. until you are ready to submit the entire manuscript. Achecklist regarding requirements for submission can be found athttp://www.aacc.org/ccj/manuscript_check02.pdf. Figures must be uploaded as ImageFiles in .tif or .eps files at 600 DPI. Alternatively, you may use PowerPointsoftware for figures but fonts must be embedded and only one image per slide,one slide per file. When uploading the revised version, please be sure toinclude in the "Response to Reviews" field a point-by-point list ofall changes made, or your rebuttal, in response to each of the reviewers?
suggestions.
P.P.S.Please note that if your manuscript. has color figures, the authors areexpected to bear the cost of printing them, except in the case of invitedpapers. The charges for these figures are $1500 for the first color figure orpart of a figure, and $500 for each additional color figure or part of afigure. Authors will be billed for color publication costs unless they requestthat their figures be printed in black and white.
该杂志一般为2个审稿人，审稿过程也较严格，都是本领域的大牛。后来我还有幸在一次会议上认识到一个当年的审稿人，但不知道是1还是2，呵呵！一般总是先鼓励一段话，不写了。。。
下面问题就来了，共12个，有些很好回答，一句话就可以解释清楚，有些就比较麻烦。还是举例说明把
--------------------------------------------------------------------------------------
1）实验的有效性和深度（at least for a few substances of major importance
detectionlimits, cut-off values and specificity should have been studied.Also the description of the assay principle is not quite clear）
没办法，只有一条路，补充相关实验，然后再投。
2）语言问题（The English text would have to be substantially improved）
虽然这是一个美国杂志，但对语言的要求一点都不弱，投之前还是忽略了，没办法，慢慢修改。
3）核心的技术问题（A cut-off value is given for MOL but the dimension is missing. Inthe discussion various anecdotic reports are given for which no data arepresented under results.）重新验证讨论。本来认为很快就可以接受了，没想到却又等了一个半月（中间发过一次信件询问）才收到回信。原来除了上次2个评委，这次又增加了一个独立审稿人。。。
原文如下：
Yourrevised manuscript. has been examined by the original two reviewers, plus arecommended third reviewer with special expertise in this area. Please visit http://submit.clinchem.org to retrieve their comments. The threereviewers find merit in the work, but have numerous constructive suggestions（别害怕，其实就是几个小问题）. Please consider these suggestions carefully and prepare animproved version that addresses these concerns. I have also noted that thereare several color figures included in the paper, which seem to be useful onlyin color. Please be aware that (should your paper be accepted for publication)authors are expected to pay the costs for publication of color figures. Thecharge for the first color figure is $1500; subsequent figures, or parts offigures, are $500 each. Of course, if you wish to submit alternate figures inblack and white (or grayscale), you may do so.
Sincerely,
Dr.xxx
Associate Editor
P.S.You will find your revised manuscript. can be uploaded in your "Submit aRevision" queue at http://submit.clinchem.org. A checklist of requirements forsubmission can be found at http://www.aacc.org/ccj/manuscript_check02.pdf. When uploading the revised version,please be sure to include in the "Response to Reviews" field apoint-by-point list of all changes made, or your rebuttal, in response to eachof the reviewer suggestions. Also, please submit copyright releases for allauthors. Our Authors' Assurances and Assignment of Copyright form. can bedownloaded from http://www.aacc.org/ccj/auth_assure02.pdf. Please note that all authors must signboth sections of the form. Send the completed form. to us by FAX(434-979-7599).P.P.S. For figures, please submit .tif files that have a minimumresolution of 600 DPI; the width and height of the Pixels should be about 4200x 4200. Alternatively, you may use PowerPoint for figures, but each .ppt filemay contain only one slide and fonts must be embedded.
总之一句话，还是需要再次修改。
又等了接近1个月时间，幸亏不是学生赶毕业，最终被接收了。
Thank you for your revised manuscript. It is acceptable and will be processed forpublication. Please note that I edited the paper to remove all text related toFigure 6. The structures of the drugs are available to anyone who wants to lookthem up. Thus this figure will not be in the proofs that you receive.
如果proof快的话，这个杂志一般会安排在2-3个月后发表。
If page proofs are returned promptly, your paper is scheduled to appear in the Octissue.之前电子版会先在网上发布Papers in press are posted online 2-6 weeks before the issue date.Issues are scheduled to be mailed to subscribers and appear on the Internetbefore the first day of the issue month. The electronic version (http://www.clinchem.org)is published at Stanford University's HighWire Press, where your article willbe linked electronically to and from PubMed and directly to and from over 340other journals that are on-line at Stanford.当然还要转移版权Priorto publication we require copyright releases signed by all authors. Our AuthorsAssurances and Assignment of Copyright form. can be downloaded from http://www.aacc.org/ccj/auth_assure02.pdf. Please note that all authors must signboth sections of the form. (a signature on the lower section means that allconflicts of interest have been disclosed even if there are none).
Thankyou for this contribution.
Sincerely,
Dr.xx
Associate Editor
我们的回复
DearDr.×××,
Thankyou very much for giving me an opportunity to revise the abovemanuscript.
Accordingto the reviewers' comments, we have revised the manuscript to provided ourexplanation.
Furthermore,we revised the paper according to your suggestion.
1)The length of abstract is 194 words, and the word of the main text is2550.
2)The layout and format guidelines have been followed.
3)The changes to the paper have been highlighted underlined as well as includingdetailed responses to the reviewers comments.
Ihope you are satisfied with the revised version, however, if there is morequestion, we are willing to revise it again.
Thank you.
××××
come from×××
